Caldesmon Antikörper (C-Term)

Produktnummer ABIN7849506

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Caldesmon in WB, IHC, IF, FACS, IHC (p) und ICC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Caldesmon Antikörper (C-Term) (ABIN7849506)

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Caldesmon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Produktdetails anti-Caldesmon Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Monoclonal Anti- Caldesmon antibody

Aufreinigung: Protein A affinity purified

Immunogen: Asynthetic peptide within C-terminal human Caldesmon.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot, WB(1:500-1:1, 000), Immunohistochemistry, IHC-P (1:20-1:100), Immunocytochemistry, ICC/IF (1:20-1:100), Flow Cytometry, Flow-Cyt (1:20-1:50),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1*PBS ( pH 7.4), 0.2 % BSA, 40 % Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu Caldesmon

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Andere Bezeichnung: Caldesmon

Hintergrund: Caldesmon is a protein that in humans is encoded by the CALD1 gene.Caldesmon (CDM) is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. Domain mapping and physical studies suggest that CDM is an elongated molecule with an N-terminal myosin/calmodulin-binding domain and a C-terminal tropomyosin/actin/calmodulin-binding domain separated by a 40-nm-long central helix.1The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells.2The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction.

Pathways: Myometrial Relaxation and Contraction