SREBF2 Antikörper (Cy3)

Produktnummer ABIN741708

Der Cy3-konjugierte Kaninchen Polyklonal anti-SREBF2 Antikörper (ABIN741708) detektiert spezifisch SREBF2 in WB und IF (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus und Schwein.

Kurzübersicht für SREBF2 Antikörper (Cy3) (ABIN741708)

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reaktivität: Human, Ratte, Maus, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SREBF2 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-SREBF2 Antikörper (Cy3)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SREBP-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SREBF2

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Andere Bezeichnung: SREBP-2

Hintergrund:

Synonyms: Sterol Regulatory Element Binding Protein-2, MGC124823, Srebf2_retired, SREBP-2, SREBP2, SRBP2_HUMAN, Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2.

Background: Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. ab30682 detects both precursor and active forms of SREBP2 in tissues and cells such as liver, brown fat, testis, HepG2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.

Molekulargewicht: 126kDa

Gen-ID: 6721

Pathways: Regulation of Lipid Metabolism by PPARalpha