Rekombinanter SIRT1 Antikörper (pSer47)

Produktnummer ABIN7828566

Der Kaninchen Monoklonal anti-SIRT1 Antikörper (Klon A810) (ABIN7828566) detektiert spezifisch SIRT1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter SIRT1 Antikörper (pSer47) (ABIN7828566)

Target: SIRT1 (Sirtuin 1 (SIRT1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SIRT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A810

Produktdetails anti-SIRT1 Antikörper

Bindungsspezifität: pSer47

Verwendungszweck: Recombinant Phospho-SIRT1(Ser47) Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: phosphorylated human SIRT1(Ser47) peptide

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000,IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu SIRT1

Target: SIRT1 (Sirtuin 1 (SIRT1))

Andere Bezeichnung: SIRT1

Hintergrund: SIR,HST,SIRT,Hsir,homolog-like,SIR2 like protein,Regulatory protein SIR2 homolog,NAD-dependent deacetylase sirtuin,Sirtuin (silent mating type information regulation 2 homolog),SIR2L,Hsirt,75SirT,sirtuin,SIRT1,SIR2,SIR2L1,SIR2alpha,sirtuin 1,75SirT1,Hsir2,Hsirt1,HST2,S.cerevisiae,NAD-dependent deacetylase sirtuin-1,Regulatory protein SIR2 homolog 1,SIR2 like protein 1,homolog-like 1,SirtT1 75 kDa fragment,Sirtuin (silent mating type information regulation 2 homolog) 1,SIR2,SIR2alpha,SIR2L1,sirtuin 1,homolog of,NAD dependent deacetylase sirtuin 1,NAD dependent protein deacetylase sirtuin 1,OTTHUMP00000198111,OTTHUMP00000198112,S. cerevisiae,SIR1,SIR2 like 1,SIR2-like protein 1,Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae),Sirtuin type 1,SIRT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARγ, and the PPARγ coactivator-1α (PGC-1α) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. Deacetylation of PPARγ and PGC-1α regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, as it is phosphorylated at Ser27 and Ser47 in vivo, however, the function of these phosphorylation sites has not yet been determined. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 82 kDa

Observed MW: 110 kDa The actual band is not consistent with the expectation.

UniProt: Q96EB6

Pathways: MAPK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling