Rekombinanter KIT Antikörper

Produktnummer ABIN7828375

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch KIT in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter KIT Antikörper (ABIN7828375)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser KIT Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: A186

Produktdetails anti-KIT Antikörper

Verwendungszweck: Recombinant c-Kit Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human c-Kit fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: IHC 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Andere Bezeichnung: c-Kit

Hintergrund: KIT,C-Kit,CD117,PBT,SCFR,Mast/stem cell growth factor receptor Kit,p145 c-kit,Piebald trait protein,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,SCFR,C Kit,CD_antigen: CD117,c-Kit Ligand,Kit Ligand,KIT oncogene,KIT proto oncogene receptor tyrosine kinase,KIT proto-oncogene receptor tyrosine kinase,Mast cell growth factor receptor,MGF,Proto oncogene c Kit,Proto oncogene tyrosine protein kinase Kit,SCF Receptor,soluble KIT variant 1,Steel Factor Receptor,Stem cell factor receptor,tyrosine protein kinase Kit,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein,Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: P10721

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity