Rekombinanter DDB2 Antikörper
Kurzübersicht für Rekombinanter DDB2 Antikörper (ABIN7828148)
Target
Alle DDB2 Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Recombinant DDB2 Monoclonal Antibody
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Aufreinigung
- Protein A purified
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Immunogen
- Recombinant human DDB2 fragment
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Isotyp
- IgG, kappa
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Applikationshinweise
- WB 1:1000,IHC 1:500-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Haltbarkeit
- 12 months
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- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
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Andere Bezeichnung
- DDB2
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Hintergrund
- DDB,UV-DDB,DDB2,DDBB,UV-DDB2,XPE,DamagedDNA-Binding Protein (DDB) consists of a 127 kDa subunit (DDB-1) and a 48 kDa subunit (DDB-2) that contribute to the formation of the UV-damaged DNA-binding protein complex (UV-DDB). In conjunction with CUL4A and ROC-1, the UV-DDB complex forms an E3 ubiquitin ligase that recognizes a broad spectrum of DNA lesions such as cyclobutane pyrimidine dimers, 6-4 photoproducts, apurinic sites and short mismatches. The complex polyubiquitinates components of the nucleotide excision repair pathway. Loss of DDB activity has been identified in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and has been linked to the deficient repair of cyclobutane pyrimidine dimers in cells derived from these patients. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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Molekulargewicht
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Calculated MW: 48 kDa
Observed MW: 48 kDa
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UniProt
- Q92466
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Pathways
- DNA Reparatur
Target
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