Rekombinanter Cyclin D1 Antikörper (pThr286)

Produktnummer ABIN7828139

Der Kaninchen Monoklonal anti-Cyclin D1 Antikörper wird verwendet zum Nachweis von Cyclin D1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC und FACS.

Kurzübersicht für Rekombinanter Cyclin D1 Antikörper (pThr286) (ABIN7828139)

Target: Cyclin D1 (CCND1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: A202

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: pThr286

Verwendungszweck: Recombinant Phospho-Cyclin D1 (Thr286) Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human Phospho-Cyclin D1 (Thr286) fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:50-1:100,FCM 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: Cyclin D1

Hintergrund: Cyl,PRAD,U21B,CCND,B cell leukemia,G1/S specific cyclin D,Cyclin D,BCL,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,B cell leukemia 1,BCL 1,Cd1,Cyl 1,G1/S specific cyclin D1,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,cyclin D1,Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 34 kDa

Observed MW: 34 kDa

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling