Retinoblastoma 1 Antikörper (AA 40-921)
Kurzübersicht für Retinoblastoma 1 Antikörper (AA 40-921) (ABIN7825771)
Target
Alle Retinoblastoma 1 (RB1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 40-921
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Verwendungszweck
- Anti-RB1 Antibody
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins
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Homologie
- Human RB1 shares 91.6%,90.7% amino acid (aa) sequence identity with mouse,rat RB1,respectively.
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Produktmerkmale
- Anti-RB1 Antibody. Tested in WB, IHC, ICC, IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat.
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Aufreinigung
- Immunogen affinity purified.
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Immunogen
- E.coli-derived human RB1 recombinant protein (Position: E40-D921). Human RB1 shares 91.6% and 90.7% amino acid (aa) sequence identity with mouse and rat RB1, respectively.
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Isotyp
- IgG
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anti-Retinoblastoma 1 (RB1) (pSer612) antibody
RB1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB7659 unconjugated
anti-Retinoblastoma 1 (RB1) (AA 586-615) antibodyRB1 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB7977 unconjugated
anti-Retinoblastoma 1 (RB1) (AA 858-886), (C-Term) antibodyRB1 Reaktivität: Human WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB20715 unconjugated
anti-Retinoblastoma 1 (RB1) (AA 745-928) antibodyRB1 Reaktivität: Human WB, ELISA, ICC, FACS Wirt: Maus Monoclonal 2A11D11 unconjugated
anti-Retinoblastoma 1 (RB1) (pSer780) antibodyRB1 Reaktivität: Human WB, IHC Wirt: Kaninchen Monoclonal unconjugated
anti-Retinoblastoma 1 (RB1) (C-Term) antibodyRB1 Reaktivität: Human WB, IF, IP, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer788) antibodyRB1 Reaktivität: Human IHC (p), DB Wirt: Kaninchen Polyclonal RB7670 unconjugated
anti-Retinoblastoma 1 (RB1) (pSer811) antibodyRB1 Reaktivität: Human IF, IHC (p), DB Wirt: Kaninchen Polyclonal RB7679 unconjugated
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Applikationshinweise
- Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/mL
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. -
Haltbarkeit
- 12 months
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- Retinoblastoma 1 (RB1)
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Andere Bezeichnung
- RB1
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Hintergrund
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Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Gene Full Name: RB transcriptional corepressor 1
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Molekulargewicht
- 110 kDa
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Gen-ID
- 5925
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UniProt
- P06400
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Pathways
- Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie
Target
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