Rekombinanter PD-1 Antikörper

Produktnummer ABIN7795529

Dieser Maus Bispecific Antikörper detektiert spezifisch PD-1 in FACS, IHC, WB, ELISA, ICC und in vivo. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für Rekombinanter PD-1 Antikörper (ABIN7795529)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Maus

Klonalität: Bispecific

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunocytochemistry (ICC), In vivo Studies (in vivo)

Güteklasse: In vivo Grade

Klon: 29F-1A12-1-RMP1-14-1

Produktdetails anti-PD-1 Antikörper

Expressionssystem: Mammalian cells

Verwendungszweck: In Vivo Grade Recombinant Anti-mouse PD-1 / PD-1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 29F.1A12.1 / RMP1-14.1)

Produktmerkmale: Are you looking for a better anti-mouse PD-1 monoclonal antibody than the clones of RMP1-14 and 29F.1A12. The rat anti-mouse PD-1 monoclonal antibodies (clone No. RMP1-14, rat IgG2a kappa, and clone No. 29F.1A12, rat IgG2a kappa) bind to different epitopes of the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. Both RMP1-14 and 29F.1A12 antibodies block the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein. It is under investigation whether either of the recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (RMP1-14 / 29F.1A12 and 29F.1A12 / RMP1-14) is the best anti-mouse PD1 antibody. Our recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (combination of RMP1-14 and 29F.1A12) have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14 and 29F.1A12).

Aufreinigung: Protein A or G affinity column

Reinheit: >95 % by reducing SDS-PAGE

Endotoxin-Niveau: < 1 EU per 1 mg of the protein by the LAL method

Isotyp: IgG2c, L234A, L235A, P329G, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: > 3 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: PD-1 & PD-1

Sub Type: Bispecific

Pathways: Cancer Immune Checkpoints