VEGFR2/CD309 Antikörper (pTyr1175)
Kurzübersicht für VEGFR2/CD309 Antikörper (pTyr1175) (ABIN7674409)
Target
Alle VEGFR2/CD309 (VEGFR2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pTyr1175
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Verwendungszweck
- Phospho-VEGF Receptor 2 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500 - 1:1000, IHC: 1:50 - 1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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Haltbarkeit
- 12 months
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- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
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Andere Bezeichnung
- VEGF Receptor 2
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Hintergrund
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Synonyms: Vascular endothelial growth factor receptor 2 (VEGFR-2)|Fetal liver kinase 1 (FLK-1)|Kinase insert domain receptor (KDR)|Protein-tyrosine kinase receptor flk-1|KDR|FLK1|VEGFR2
Background: KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
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Molekulargewicht
- 250 kDa
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Gen-ID
- 3791
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UniProt
- P35968
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Pathways
- RTK Signalweg, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
Target
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