PRTN3 Antikörper

Produktnummer ABIN7670731

Dieses Anti-PRTN3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRTN3 in ELISA. Geeignet für Human.

Kurzübersicht für PRTN3 Antikörper (ABIN7670731)

Target: PRTN3 (Proteinase 3 (PRTN3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRTN3 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-PRTN3 Antikörper

Verwendungszweck: Proteinase 3/PRTN3/PR3 Polyclonal Antibody(Capture/Detector)

Aufreinigung: Antigen Affinity Purification

Immunogen: Recombinant Human Proteinase 3/PRTN3/PR3 protein expressed by Mammalian

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Andere Bezeichnung: Proteinase 3/PRTN3

Hintergrund: AGP,PRTN,proteinase,Leukocyte proteinase,Neutrophil proteinase,ACPA,AGP7,C-ANCA,CANCA,MBN,MBT,NP-4,NP4,P29,PR-3,PR3,PRTN3,proteinase 3,Myeloblastin,C-ANCA antigen,Leukocyte proteinase 3,Neutrophil proteinase 4,Wegener autoantigen,Proteinase 3 (PRTN3), also known as Myeloblastin (MBN), is a 32-33 kDa member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human PRTN3 proprecursor is 231 amino acids (aa) in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221 aa mature enzyme (aa 28-248), and an eight aa C?terminal propeptide (aa 249-256). Within the cell, a 35 kDa immature form exists, on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa 26-249, human PRTN3 shares 68 % aa identity with mouse PRTN3.

UniProt: P24158