PRTN3 Antikörper

Produktnummer ABIN969498

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-PRTN3 Antikörper (Klon 3B4) (ABIN969498) detektiert spezifisch PRTN3 in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PRTN3 Antikörper (ABIN969498)

Target: PRTN3 (Proteinase 3 (PRTN3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRTN3 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 3B4

Produktdetails anti-PRTN3 Antikörper

Verwendungszweck: Proteinase 3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PRTN3 Antikörper (ABIN969498)

Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: "Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis." in: Blood, Vol. 110, Issue 12, pp. 4086-95, (2007) (PubMed).

Abdgawad, Hellmark, Gunnarsson, Westman, Segelmark: "Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism." in: Clinical and experimental immunology, Vol. 145, Issue 1, pp. 63-70, (2006) (PubMed).

Details zu PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Andere Bezeichnung: Proteinase 3

Hintergrund: Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Molekulargewicht: 28 kDa

Gen-ID: 5657

UniProt: P24158