PD-1 Antikörper (CF®488A)

Produktnummer ABIN7658970

Dieses Anti-PD-1-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von PD-1 in FACS und Func. Geeignet für Maus.

Kurzübersicht für PD-1 Antikörper (CF®488A) (ABIN7658970)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist konjugiert mit CF®488A

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: RMP1-14

Produktdetails anti-PD-1 Antikörper (CF®488A)

Verwendungszweck: PD1, Mouse(RMP1-14), CF488A conjugate

Produktmerkmale: PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: PDCD1 transfected BHK cells

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: Spleen, Thymus or Lymph Node.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: PD1

Hintergrund:

Synonyms: CD279, CD279 antigen, PD1, PDCD1, Programmed cell death 1, Programmed cell death protein 1, Systemic lupus erythematosus susceptibility 2 (SLEB2)

Tissue Expression: B-cells|Myeloid cells|T-cells

Molekulargewicht: ~50-55 kDa

Gen-ID: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints