Rekombinanter IL3RA Antikörper (AA 26-171) (CF®594)

Produktnummer ABIN7655702

Der Kaninchen Monoklonal Anti-IL3RA-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, IL3RA in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter IL3RA Antikörper (AA 26-171) (CF®594) (ABIN7655702)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser IL3RA Antikörper ist konjugiert mit CF®594

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: IL3RA-2947R

Produktdetails anti-IL3RA Antikörper (CF®594)

Bindungsspezifität: AA 26-171

Verwendungszweck: IL3RA / CD123 (Acute Myeloid Leukemia Marker)(IL3RA/2947R), CF594 conjugate

Produktmerkmale: CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human IL3RA protein (around aa 26-171)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: THP-1, RPMI-8226 or HDLM-2 cells. Tonsil, Lymph Node or Stomach

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Andere Bezeichnung: CD123

Hintergrund:

Synonyms: CD123, hIL3Ra, IL-3R-alpha, IL-3RA, IL3RAX, IL3RAY, IL3RX, IL3RY, Interleukin-3 Receptor, alpha, Interleukin3 receptor, Interleukin3 receptor, Y-chromosomal

Gene Symbol: IL3RA

Molekulargewicht: 70 kDa

Gen-ID: 3563

UniProt: P26951

Pathways: JAK-STAT Signalweg