Cadherin-16 Antikörper (AA 371-507)

Produktnummer ABIN7650275

Der Maus Monoklonal Anti-Cadherin-16-Antikörper wurde für IHC, WB und IHC (fp) validiert. Er ist geeignet, Cadherin-16 in Proben von Human zu detektieren.

Kurzübersicht für Cadherin-16 Antikörper (AA 371-507) (ABIN7650275)

Target: Cadherin-16 (CDH16)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cadherin-16 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: CDH16-2125

Produktdetails anti-Cadherin-16 Antikörper

Bindungsspezifität: AA 371-507

Verwendungszweck: Ksp-Cadherin / CDH16 (Renal Cell Marker)(CDH16/2125)

Produktmerkmale: This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 371-507) of human CDH16 protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: Normal kidney or renal cell carcinoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Cadherin-16

Target: Cadherin-16 (CDH16)

Andere Bezeichnung: CDH16

Hintergrund:

Synonyms: Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody

Gene Symbol: CDH16

Tissue Expression: Epithelial cells

Molekulargewicht: 130 kDa

Gen-ID: 1014

UniProt: O75309