APC Antikörper (AA 1-433)

Produktnummer ABIN7649179

Dieses Maus Monoklonal-Antikörper erkennt spezifisch APC in WB, IHC, IP und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für APC Antikörper (AA 1-433) (ABIN7649179)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: ALi 12-28

Produktdetails anti-APC Antikörper

Bindungsspezifität: AA 1-433

Verwendungszweck: APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor)(ALi 12-28)

Produktmerkmale: Adenomatous Polyposis Coli (APC) is a protein with many cellular functions. It is a tumor suppressor and negative regulator of Wnt signaling. APC has roles in cell adhesion and cell migration. Mutations in APC are assuciated with several diseases. The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human APC protein (around aa 1-433)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: COLO 320DM whole cell lysate. HCT116 cells. Tonsil, placenta, breast or colon.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: Adenomatous Polyposis Coli

Hintergrund:

Synonyms: Adenomatous Polyposis Coli, APC, CC1, Deleted in polyposis 2.5, Protein Phosphatase 1, Regulatory Subunit 46, DP2, DP3

Gene Symbol: APC

Molekulargewicht: 66 kDa

Gen-ID: 324

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization