IL-8 Antikörper (AA 31-99)

Produktnummer ABIN728053

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL-8 in WB, ELISA, IHC (p), IHC (fro), IF (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Human, Kaninchen, Maus und Ratte und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für IL-8 Antikörper (AA 31-99) (ABIN728053)

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Reaktivität: Human, Kaninchen, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-IL-8 Antikörper

Bindungsspezifität: AA 31-99

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL-8 Antikörper (ABIN728053)

Xu, Huang, Zhang, Li, Zheng, Yu, Chu, Lin, Chen: "Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis." in: Molecular medicine reports, Vol. 13, Issue 5, pp. 4167-74, (2017) (PubMed).

Zhang, Tseng, Zhang, Sirin, Corn, Li-Ning-Tapia, Troncoso, Davis, Pettaway, Ward, Frazier, Logothetis, Kolonin: "CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment." in: Nature communications, Vol. 7, pp. 11674, (2016) (PubMed).

Huang, Duan, Qian, Fan, Lv, Zhang, Han, Wu, Guo, Hu, Du, Chen, Jin: "IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma." in: Scientific reports, Vol. 6, pp. 36551, (2016) (PubMed).

Lu, Wei, Shao, Tang, Huang, Zhang, Yang, Jing: "Assessment of atherosclerotic plaques in the rabbit abdominal aorta with interleukin-8 monoclonal antibody-targeted ultrasound microbubbles." in: Molecular biology reports, Vol. 40, Issue 4, pp. 3083-92, (2013) (PubMed).

Ma, Niu, Sun, Wang, Luo, Zhang, Wang: "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." in: Archives of toxicology, Vol. 86, Issue 6, pp. 849-56, (2012) (PubMed).

Details zu IL-8

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Andere Bezeichnung: IL-8

Hintergrund:

Synonyms: IL8, NAF, GCP1, LECT, LUCT, NAP1, GCP-1, LYNAP, MDNCF, MONAP, NAP-1, Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, Monocyte-derived neutrophil chemotactic factor, Monocyte-derived neutrophil-activating peptide, Neutrophil-activating protein 1, Protein 3-1C, T-cell chemotactic factor, CXCL8

Background: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-1-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Gen-ID: 3576

UniProt: P10145

Pathways: TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagie