GZMB Antikörper

Produktnummer ABIN7605016

Der Kaninchen-Monoklonal Anti-GZMB-Antikörper wurde für IHC, IF, IP und ICC validiert. Er ist geeignet zum Nachweis von GZMB in Proben aus Human. }

Kurzübersicht für GZMB Antikörper (ABIN7605016)

Target: GZMB (Granzyme B (GZMB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: AAHC-7

Produktdetails anti-GZMB Antikörper

Verwendungszweck: Anti-Granzyme B GZMB Monoclonal Antibody

Produktmerkmale: Anti-Granzyme B GZMB Monoclonal Antibody (ABIN7605016). Tested in IHC, ICC/IF, IP applications. This antibody reacts with Human.

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Konzentration: 0.5 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: GZMB

Hintergrund:

Synonyms: Leptin receptor,LEP-R,HuB219,OB receptor,OB-R,CD295,LEPR,DB, OBR,

Tissue Specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

Molekulargewicht: 23 kDa

UniProt: P10144

Pathways: Apoptose, Caspase Kaskade in der Apoptose