KIF7 Antikörper (Middle Region)

Produktnummer ABIN7603065

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KIF7 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für KIF7 Antikörper (Middle Region) (ABIN7603065)

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIF7 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-KIF7 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-KIF7 Antibody Picoband® (ABIN7603065). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human KIF7, identical to the related mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
1. Al-Gazali, L. I., Bakalinova, D. Autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance. Clin. Dysmorph. 7: 177-184, 1998. 2. Ali, B. R., Silhavy, J. L., Akawi, N. A., Gleeson, J. G., Al-Gazali, L. A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance. Orphanet J. Rare Dis. 7: 27, 2012. Note: Electronic Article. 3. Dafinger, C., Liebau, M. C., Elsayed, S. M., Hellenbroich, Y., Boltshauser, E., Korenke, G. C., Fabretti, F., Janecke, A. R., Ebermann, I., Nurnberg, G., Nurnberg, P., Zentgraf, H., Koerber, F., Addicks, K., Elsobky, E., Benzing, T., Schermer, B., Bolz, H. J. Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J. Clin. Invest. 121: 2662-2667, 2011.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu KIF7

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Andere Bezeichnung: KIF7

Hintergrund:

Synonyms: Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD123, IL3RA, IL3R

Tissue Specificity: Brain.

Background: This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

Molekulargewicht: 151 kDa

Gen-ID: 374654

UniProt: Q2M1P5

Pathways: Hedgehog Signalweg