ALDH6A1 Antikörper (C-Term)
Kurzübersicht für ALDH6A1 Antikörper (C-Term) (ABIN7602810)
Target
Alle ALDH6A1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Verwendungszweck
- Anti-ALDH6A1 Antibody Picoband®
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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Produktmerkmale
- Anti-ALDH6A1 Antibody Picoband® (ABIN7602810). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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Aufreinigung
- Immunogen affinity purified.
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Immunogen
- A synthetic peptide corresponding to a sequence at the C-terminus of human ALDH6A1, identical to the related mouse and rat sequences.
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Isotyp
- IgG
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Applikationshinweise
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. Chambliss, K. L., Gray, R. G. F., Rylance, G., Pollitt, R. J., Gibson, K. M. Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency. J. Inherit. Metab. Dis. 23: 497-504, 2000. 2. Dobrowolski, S. F., Alodaib, A., Karunanidhi, A., Basu, S., Holecko, M., Lichter-Konecki, U., Pappan, K. L., Vockley, J. Clinical, biochemical, mitochondrial, and metabolomic aspects of methylmalonate semialdehyde dehydrogenase deficiency: report of a fifth case. Molec. Genet. Metab. 129: 272-277, 2020. 3. Gray, R. G. F., Pollitt, R. J., Webley, J. Methylmalonic semialdehyde dehydrogenase deficiency: demonstration of defective valine and beta-alanine metabolism and reduced malonic semialdehyde dehydrogenase activity in cultured fibroblasts. Biochem. Med. Metab. Biol. 38: 121-124, 1987. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- ALDH6A1 (Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1))
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Andere Bezeichnung
- ALDH6A1
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Hintergrund
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Synonyms: Pannexin-2, PANX2
Tissue Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Background: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) is an enzyme that in humans is encoded by the ALDH6A1 gene. This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.
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Molekulargewicht
- 58 kDa
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Gen-ID
- 4329
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UniProt
- Q02252
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Pathways
- Brown Fat Cell Differentiation
Target
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