Presenilin 2 Antikörper (C-Term)

Produktnummer ABIN7602796

Der Kaninchen Polyklonal Anti-Presenilin 2-Antikörper wurde für WB, IHC, IF, FACS und ICC validiert. Er ist geeignet, Presenilin 2 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für Presenilin 2 Antikörper (C-Term) (ABIN7602796)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-Presenilin 2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-Presenilin 2/AD5/PSEN2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Presenilin 2/AD5/PSEN2 Antibody Picoband® (ABIN7602796). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Presenilin 2/AD5/PSEN2, identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Mouse, Rat
1. Muller, U., Winter, P., Graeber, M. B. Alois Alzheimer's case, Auguste D., did not carry the N141I mutation in PSEN2 characteristic of Alzheimer disease in Volga Germans. (Letter) Arch. Neurol. 68: 1210-1211, 2011. 2. Piscopo, P., Marcon, G., Piras, M. R., Crestini, A., Campeggi, L. M., Deiana, E., Cherchi, R., Tanda, F., Deplano, A., Vanacore, N., Tagliavini, F., Pocchiari, M., Giaccone, G., Confaloni, A. A novel PSEN2 mutation associated with a peculiar phenotype. Neurology 70: 1549-1554, 2008. 3. Yu, C.-E., Marchani, E., Nikisch, G., Muller, U., Nolte, D., Hertel, A., Wijsman, E. M., Bird, T. D. The N141I mutation in PSEN2: implications for the quintessential case of Alzheimer disease. Arch. Neurol. 67: 631-633, 2010.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Andere Bezeichnung: PSEN2

Hintergrund:

Synonyms: Fibrinogen gamma chain,FGG,PRO2061,

Tissue Specificity: Detected in blood plasma (at protein level). .

Background: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either ly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Molekulargewicht: 34 kDa, 50 kDa

Gen-ID: 5664

UniProt: P49810

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung