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LDLR Antikörper (AA 705-860)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LDLR in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7602357

Kurzübersicht für LDLR Antikörper (AA 705-860) (ABIN7602357)

Target

Alle LDLR Antikörper anzeigen
LDLR (Low Density Lipoprotein Receptor (LDLR))

Reaktivität

  • 89
  • 43
  • 29
  • 17
  • 16
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 80
  • 15
  • 5
Kaninchen

Klonalität

  • 76
  • 23
  • 1
Polyklonal

Konjugat

  • 59
  • 7
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LDLR Antikörper ist unkonjugiert

Applikation

  • 70
  • 40
  • 30
  • 28
  • 16
  • 14
  • 13
  • 11
  • 8
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Bindungsspezifität

    • 16
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 705-860

    Verwendungszweck

    Anti-LDLR Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-LDLR Antibody Picoband® (ABIN7602357). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human LDLR recombinant protein (Position: A705-A860).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Aalto-Setala, K., Helve, E., Kovanen, P. T., Kontula, K. Finnish type of low absorbance lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization-defective phenotype. J. Clin. Invest. 84: 499-505, 1989. 2. Aalto-Setala, K., Koivisto, U.-M., Miettinen, T. A., Gylling, H., Kesaniemi, Y. A., Savolainen, M., Pyorala, K., Ebeling, T., Mononen, I., Turtola, H., Viikari, J., Kontula, K. Prevalence and geographical distribution of major LDL receptor gene rearrangements in Finland. J. Intern. Med. 231: 227-234, 1992. 3. Agnello, V., Abel, G., Elfahal, M., Knight, G. B., Zhang, Q.-X. Hepatitis C virus and other flaviviridae viruses enter cells via low absorbance lipoprotein receptor. Proc. Nat. Acad. Sci. 96: 12766-12771, 1999.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    LDLR (Low Density Lipoprotein Receptor (LDLR))

    Andere Bezeichnung

    LDLR

    Hintergrund

    Synonyms: Low-density lipoprotein receptor, LDL receptor, LDLR

    Tissue Specificity: Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

    Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low absorbance lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low absorbance lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

    Molekulargewicht

    140-160 kDa

    Gen-ID

    3949

    UniProt

    P01130

    Pathways

    Hepatitis C, Lipid Metabolism
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