ROR2 Antikörper (AA 499-547)

Produktnummer ABIN7601866

Der Kaninchen Polyklonal Anti-ROR2-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, ROR2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ROR2 Antikörper (AA 499-547) (ABIN7601866)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-ROR2 Antikörper

Bindungsspezifität: AA 499-547

Verwendungszweck: Anti-ROR2 Antibody Picoband®

Produktmerkmale: Anti-ROR2 Antibody Picoband® (ABIN7601866). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ROR2 recombinant protein (Position: E499-Q547). Human ROR2 shares 93.9% amino acid (aa) sequence identity with mouse ROR2.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Afzal, A. R., Jeffery, S. One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum. Mutat. 22: 1-11, 2003. 2. Afzal, A. R., Rajab, A., Fenske, C. D., Oldridge, M., Elanko, N., Ternes-Pereira, E., Tuysuz, B., Murday, V. A., Patton, M. A., Wilkie, A. O. M., Jeffery, S. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nature Genet. 25: 419-422, 2000. 3. Ali, B. R., Jeffery, S., Patel, N., Tinworth, L. E., Meguid, N., Patton, M. A., Afzal, A. R. Novel Robinow syndrome causing mutations in the proximal region of the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum. Hum. Genet. 122: 389-395, 2007.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Andere Bezeichnung: ROR2

Hintergrund: Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Molekulargewicht: 105 kDa

Gen-ID: 4920

UniProt: Q01974

Pathways: RTK Signalweg, WNT Signalweg