Exonuclease 1 Antikörper (AA 25-846)

Produktnummer ABIN7600922

Dieses Anti-Exonuclease 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Exonuclease 1 in WB, ELISA, IF und ICC. Geeignet für Human.

Kurzübersicht für Exonuclease 1 Antikörper (AA 25-846) (ABIN7600922)

Target: Exonuclease 1 (EXO1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Exonuclease 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-Exonuclease 1 Antikörper

Bindungsspezifität: AA 25-846

Verwendungszweck: Anti-Exonuclease 1/EXO1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Exonuclease 1/EXO1 Antibody Picoband® (ABIN7600922). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Exonuclease 1/EXO1 recombinant protein (Position: Q25-Q846).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1.Zakharyevich K, Tang S, Ma Y, Hunter N (2012). "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47. 2. Wilson DM III, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE (September 1998). "Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1". Nucleic Acids Res. 26 (16): 3762-8. doi:10.1093/nar/26.16.3762. 3. Schmutte C, Marinescu RC, Sadoff MM, Guerrette S, Overhauser J, Fishel R (November 1998). "Human exonuclease I interacts with the mismatch repair protein hMSH2". Cancer Res. 58 (20): 4537-42.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Exonuclease 1

Target: Exonuclease 1 (EXO1)

Andere Bezeichnung: EXO1

Hintergrund:

Synonyms: Exodeoxyribonuclease 1, Exodeoxyribonuclease I, EXO I, Exonuclease I, Protein DHS1, EXO1, DHS1, YOR033C, OR26.23

Tissue Specificity: Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.

Background: Exonuclease 1is anenzymethat in humans is encoded by theEXO1gene. It is mapped to 1q43. This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.

Molekulargewicht: 120 kDa

Gen-ID: 9156

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response