PDIA6 Antikörper (AA 20-440)

Produktnummer ABIN7600554

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PDIA6 in WB, IHC, IF, FACS und ICC. Er zeigt eine Reaktivität gegenüber Human und Affe.

Kurzübersicht für PDIA6 Antikörper (AA 20-440) (ABIN7600554)

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDIA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 3H5E7

Produktdetails anti-PDIA6 Antikörper

Bindungsspezifität: AA 20-440

Verwendungszweck: Anti-PDIA6 Antibody Picoband® (monoclonal, 3H5E7)

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PDIA6 Antibody Picoband® (monoclonal, 3H5E7) (ABIN7600554). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PDIA6 recombinant protein (Position: L20-L440).

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Chaudhuri, M. M., Tonin, P. N., Lewis, W. H., Srinivasan, P. R. The gene for a novel protein, a member of the protein disulphide isomerase/Form I phosphoinositide-specific phospholipase C family, is amplified in hydroxyurea-resistant cells. Biochem. J. 281: 645-650, 1992. 2. Hayano, T., Kikuchi, M. Cloning and sequencing of the cDNA encoding human P5. Gene 164: 377-378, 1995. 3. Hoshijima, K., Metherall, J. E., Grunwald, D. J. A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries. Genes Dev. 16: 2518-2529, 2002.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PDIA6

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Andere Bezeichnung: PDIA6

Hintergrund:

Synonyms: Eukaryotic translation initiation factor 6, eIF-6, B (2)GCN homolog, B4 integrin interactor, CAB, p27 (BBP), EIF6, EIF3A, ITGB4BP, OK/SW-cl.27

Tissue Specificity: Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle.

Background: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 48 kDa

Gen-ID: 10130

UniProt: Q15084

Pathways: ER-Nucleus Signaling, Cell RedoxHomeostasis