MYBL1 Antikörper (AA 199-752)

Produktnummer ABIN7600460

Dieses Anti-MYBL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MYBL1 in WB, ELISA und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MYBL1 Antikörper (AA 199-752) (ABIN7600460)

Target: MYBL1 (Myb-Like Protein 1 (MYBL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYBL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-MYBL1 Antikörper

Bindungsspezifität: AA 199-752

Verwendungszweck: Anti-v-Myb/MYBL1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-v-Myb/MYBL1 Antibody Picoband® (ABIN7600460). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human v-Myb/MYBL1 recombinant protein (Position: K199-L752).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Barletta, C., Druck, T., LaForgia, S., Calabretta, B., Drabkin, H., Patterson, D., Croce, C. M., Huebner, K. Chromosome locations of the MYB related genes, AMYB and BMYB. Cancer Res. 51: 3821-3824, 1991. 2. Nomura, N., Takahashi, M., Matsui, M., Ishii, S., Date, T., Sasamoto, S., Ishizaki, R. Isolation of human cDNA clones of MYB-related genes, A-MYB and B-MYB. Nucleic Acids Res. 16: 11075-11089, 1988. Note: Erratum: Nucleic Acids Res. 17: 1282 only, 1989. 3. Takahashi, T., Nakagoshi, H., Sarai, A., Nomura, N., Yamamoto, T., Ishii, S. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. FEBS Lett. 358: 89-96, 1995.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu MYBL1

Target: MYBL1 (Myb-Like Protein 1 (MYBL1))

Andere Bezeichnung: MYBL1

Hintergrund:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16, USP16, MSTP039

Tissue Specificity: Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Background: MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t (14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.

Molekulargewicht: 86 kDa

Gen-ID: 4603

UniProt: P10243

Pathways: Zellzyklus, Chromatin Binding