SPTAN1 Antikörper (AA 1916-2472)

Produktnummer ABIN7600436

Dieses Anti-SPTAN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SPTAN1 in WB, IHC, ICC, ELISA, IF und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für SPTAN1 Antikörper (AA 1916-2472) (ABIN7600436)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-SPTAN1 Antikörper

Bindungsspezifität: AA 1916-2472

Verwendungszweck: Anti-NEAS/SPTAN1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-NEAS/SPTAN1 Antibody Picoband® (ABIN7600436). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human NEAS/SPTAN1 recombinant protein (Position: E1916-S2472).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Barton, D. E., Yang-Feng, T. L., Leto, T., Marchesi, V., Francke, U. NEAS encoding a non-erythroid alpha-spectrin is on chromosome 9, region q33-q34 and on mouse chromosome 2. (Abstract) Cytogenet. Cell Genet. 46: 578, 1987. 2. Birkenmeier, C. S., McFarland-Starr, E. C., Barker, J. E. Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man. Proc. Nat. Acad. Sci. 85: 8121-8125, 1988. 3. Cianci, C. D., Zhang, Z., Pradhan, D., Morrow, J. S. Brain and muscle express a unique alternative transcript of alpha-II spectrin. Biochemistry 38: 15721-15730, 1999.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: SPTAN1

Hintergrund:

Synonyms: AF4/FMR2 family member 4,ALL1-fused gene from chromosome 5q31 protein,Protein AF-5q31,Major CDK9 elongation factor-associated protein,AFF4,AF5Q31, MCEF,HSPC092,

Tissue Specificity: Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain. .

Background: Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Molekulargewicht: 285 kDa

Gen-ID: 6709

UniProt: Q13813

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization