POT1 Antikörper (AA 15-638)

Produktnummer ABIN7600116

Der Kaninchen Polyklonal Anti-POT1-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, POT1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für POT1 Antikörper (AA 15-638) (ABIN7600116)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-POT1 Antikörper

Bindungsspezifität: AA 15-638

Verwendungszweck: Anti-POT1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-POT1 Antibody Picoband® (ABIN7600116). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived rat POT1 recombinant protein (Position: N15-V638).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL,
1. "Entrez Gene: POT1 POT1 protection of telomeres 1 homolog (S. pombe)". 2. Baumann P, Cech TR (May 2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans". Science 292 (5519): 1171-5. 3. Baumann P, Podell E, Cech TR (Oct 2002). "Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative Splicing". Mol Cell Biol 22 (22): 8079-87.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Andere Bezeichnung: Pot1

Hintergrund:

Synonyms: Nucleoprotein TPR, Megator, NPC-associated intranuclear protein, Translocated promoter region protein, TPR

Tissue Specificity: Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.

Background: Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Molekulargewicht: 71 kDa

Gen-ID: 500054

UniProt: A0A0G231

Pathways: Zellzyklus, Telomere Maintenance