Lactate Dehydrogenase A Antikörper (AA 1-332)

Produktnummer ABIN7596077

Dieses Anti-Lactate Dehydrogenase A-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Lactate Dehydrogenase A in WB, ELISA, IF und ICC. Geeignet für Human.

Kurzübersicht für Lactate Dehydrogenase A Antikörper (AA 1-332) (ABIN7596077)

Target: Lactate Dehydrogenase A (LDHA)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lactate Dehydrogenase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: AT1A4

Produktdetails anti-Lactate Dehydrogenase A Antikörper

Bindungsspezifität: AA 1-332

Verwendungszweck: Human Lactate Dehydrogenase A/LDHA antibody

Aufreinigung: protein-A affinity chromatography

Immunogen: Recombinant human LDHA (1-332aa) purified from E.coli

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu Lactate Dehydrogenase A

Target: Lactate Dehydrogenase A (LDHA)

Andere Bezeichnung: Lactate Dehydrogenase A/LDHA

Hintergrund: Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.

NCBI Accession: NP_005557

Pathways: Warburg Effekt