HCN1 Antikörper (AA 778-910)

Produktnummer ABIN7595944

Dieses Anti-HCN1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von HCN1 in WB, IHC, IP, ICC und IEM. Geeignet für Ratte.

Kurzübersicht für HCN1 Antikörper (AA 778-910) (ABIN7595944)

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM)

Klon: N70-28

Produktdetails anti-HCN1 Antikörper

Bindungsspezifität: AA 778-910

Verwendungszweck: Anti-HCN1 Antibody

Spezifität: No off-targets reported for HCN2

Kreuzreaktivität: Wüstenrennmaus, Human, Maus, Non-Human Primate, Ratte

Produktmerkmale:

Description: Our Anti-HCN1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N70/28. It is KO validated, detects human, mouse, and rat HCN1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Manufacturer Comment: We produce our HCN1 mouse monoclonal primary antibody from hybridoma clone N70/28. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Reinheit: > 90 % specific antibody

Immunogen: Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (accession number Q9JKB0), Mouse: 96% identity (128/133 amino acids identical) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Dilution Range: IP: 10 μg

Dilution Range: IHC: 1:500

Dilution Range: ICC: 1:100

Dilution Range: WB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.38

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 24 months

Details zu HCN1

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Andere Bezeichnung: HCN1

Hintergrund:

Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Target Description: HCN1 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN1 is found in the hippocampus, neocortex, and cerebellar cortex of brain. Alterations in this protein have been implicated in the disease early infantile epileptic encephalopathy.

Gene Name Alternatives: Hcn1

Molekulargewicht: 100 kDa

Pathways: Asymmetric Protein Localization