Serotonin Receptor 6 Antikörper (Extracellular)

Produktnummer ABIN7581901

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Serotonin Receptor 6 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für Serotonin Receptor 6 Antikörper (Extracellular) (ABIN7581901)

Target: Serotonin Receptor 6 (HTR6)

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Serotonin Receptor 6 Antikörper

Bindungsspezifität: AA 167-181, Extracellular

Verwendungszweck: A Rabbit Polyclonal antibody to 5HT6 Receptor (HTR6) (extracellular).

Sequenz: (C)HELGKARTPA PGQ(S)R

Spezifität: Extracellular, 2nd loop.

Homologie: Rat - 14 out of 15 amino acid residues identical Mouse - 13 out of 15 amino acid residues identical The antibody is not recommended for human samples

Produktmerkmale: Anti-5HT6 Receptor (HTR6) (extracellular) Antibody (ABIN7581901) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize 5HT6 from mouse and rat samples. The antibody is not recommended for human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)HELGKARTPAPGQ(S)R, corresponding to amino acid residues 167 - 181 of rat HTR6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu Serotonin Receptor 6

Target: Serotonin Receptor 6 (HTR6)

Andere Bezeichnung: HTR6

Hintergrund: 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, 5-HT-6, 5HT6R,5HT6 also known as 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, or 5-HT-6, is a member of the serotonin (5-HT) family of receptors that comprises 14 members, classified into 7 distinct families (5HT1 to 5HT7). With the exception of 5HT3 that is a ligand-gated channel, all other family members are G protein-coupled receptors (GPCRs) 1,2.The 5HT6 receptor is almost exclusively present in the central nervous system and is distributed in various brain regions, including the striatum, nucleus accumbens, hippocampus, thalamus, cerebellum, dentate gyrus, olfactory tubercles, amygdala, and cerebral cortex.1,2,5Based on the unique expression pattern of 5HT6 in the brain, research on the 5HT6 receptor has suggested its involvement in various neurological and psychiatric conditions, including mood disorders, schizophrenia, cognitive function and Alzheimer's disease 1,2,5. Indeed several antagonists of 5HT6 receptor have been examined in the context of schizophrenia3, Alzheimer's disease4 and cognitive impairment 5.

Gen-ID: 64354

UniProt: P31388

Pathways: JAK-STAT Signalweg