SOCS1 Antikörper (AA 121-211)

Produktnummer ABIN725135

Der Kaninchen Polyklonal Anti-SOCS1-Antikörper wurde für ELISA, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, SOCS1 in Proben von Human zu detektieren.

Kurzübersicht für SOCS1 Antikörper (AA 121-211) (ABIN725135)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SOCS1 Antikörper

Bindungsspezifität: AA 121-211

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Socs 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1

Hintergrund:

Synonyms: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, TIP-3, SOCS1

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Gen-ID: 8651

UniProt: O15524

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus