Rekombinanter TLR7 Antikörper

Produktnummer ABIN7543380

Der Kaninchen Chimeric Anti-TLR7-Antikörper wurde für ELISA und FACS validiert. Er ist geeignet, TLR7 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter TLR7 Antikörper (ABIN7543380)

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser TLR7 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Klon: LTM3

Produktdetails anti-TLR7 Antikörper

Verwendungszweck: Anti-TLR7 [LTM3], Rabbit IgG, kappa

Spezifität: This antibody binds human toll-like receptor 7 (TLR7). It also cross reacts with monkey TLR7. It is an endosomal receptor that plays a key role in innate and adaptive immunity. It also controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. TLR7 is considered to be a useful marker in indicating pathological condition of autoimmune diseases.

Kreuzreaktivität: Affe

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing TLR7 deficient BALB/mice with Ba/F3 cell line expressing hTLR7-Flag-Hisx6/hUnc93B1-HAx2 mixed with a suitable adjuvant.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody was used in combination with another anti-TLR7 antibody called rE3 to detect human TLR7 in a sandwich ELISA. LTM3 was used as used as a capturing antibody and biotinylated rE3 antibody (rE3-bio) was used a detecting antibody. This antibody can be used for the detection of human TLR7 in serum or plasma derived from human peripheral blood. The binding ability of this antibody for Ba/F3 cell line expressing human TLR7, mouse TLR7 and monkey TLR7 was checked using flow cytometry. This antibody can successfully detect human and monkey TLR7, but not mouse TLR7 in a flow cytometry (US20210199667).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Andere Bezeichnung: TLR7

Hintergrund: Toll-like receptor 7, UNQ248/PRO285

UniProt: Q9NYK1

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades