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Rekombinanter TLR7 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TLR7 in ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7543379

Kurzübersicht für Rekombinanter TLR7 Antikörper (ABIN7543379)

Target

Alle TLR7 Antikörper anzeigen
TLR7 (Toll-Like Receptor 7 (TLR7))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 95
  • 45
  • 9
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 93
  • 19
Maus

Klonalität

  • 81
  • 30
  • 1
Monoklonal

Konjugat

  • 67
  • 8
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
Dieser TLR7 Antikörper ist unkonjugiert

Applikation

  • 65
  • 48
  • 33
  • 17
  • 14
  • 11
  • 8
  • 7
  • 4
  • 3
  • 1
  • 1
ELISA, Flow Cytometry (FACS)

Klon

LTM3
  • Verwendungszweck

    Anti-TLR7 [LTM3], Mouse IgG1, kappa

    Spezifität

    This antibody binds human toll-like receptor 7 (TLR7). It also cross reacts with monkey TLR7. It is an endosomal receptor that plays a key role in innate and adaptive immunity. It also controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. TLR7 is considered to be a useful marker in indicating pathological condition of autoimmune diseases.

    Kreuzreaktivität

    Affe

    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Aufreinigung

    Protein A affinity purified

    Immunogen

    The original antibody was generated by immunizing TLR7 deficient BALB/mice with Ba/F3 cell line expressing hTLR7-Flag-Hisx6/hUnc93B1-HAx2 mixed with a suitable adjuvant.

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    This antibody was used in combination with another anti-TLR7 antibody called rE3 to detect human TLR7 in a sandwich ELISA. LTM3 was used as used as a capturing antibody and biotinylated rE3 antibody (rE3-bio) was used a detecting antibody. This antibody can be used for the detection of human TLR7 in serum or plasma derived from human peripheral blood. The binding ability of this antibody for Ba/F3 cell line expressing human TLR7, mouse TLR7 and monkey TLR7 was checked using flow cytometry. This antibody can successfully detect human and monkey TLR7, but not mouse TLR7 in a flow cytometry (US20210199667).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    PBS with 0.02 % Proclin 300.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target

    TLR7 (Toll-Like Receptor 7 (TLR7))

    Andere Bezeichnung

    TLR7

    Hintergrund

    Toll-like receptor 7, UNQ248/PRO285

    UniProt

    Q9NYK1

    Pathways

    TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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