Rekombinanter beta Catenin Antikörper

Produktnummer ABIN7543332

Der Kaninchen Chimeric Anti-beta Catenin-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, beta Catenin in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter beta Catenin Antikörper (ABIN7543332)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser beta Catenin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Klon: 3B1D11A8

Produktdetails anti-beta Catenin Antikörper

Verwendungszweck: Anti-B-catenin [3B1D11A8], Rabbit IgG, kappa

Spezifität: This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing BALB/c mice with human beta-catenin-KLH conjugate in Freund's non-complete adjuvant.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung: B-catenin

Hintergrund: CTNNB1, CTNNB, Catenin beta-1, Beta-catenin, CAT-5H10, CGMCC No. 19685

UniProt: P35222

Pathways: Peptide Hormone Metabolism