Rekombinanter Cytokeratin 18 Antikörper (Extracellular Domain)

Produktnummer ABIN7543320

Der Kaninchen Chimeric Anti-Cytokeratin 18-Antikörper wurde für ELISA validiert. Er ist geeignet, Cytokeratin 18 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter Cytokeratin 18 Antikörper (Extracellular Domain) (ABIN7543320)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Cytokeratin 18 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: HH156

Produktdetails anti-Cytokeratin 18 Antikörper

Bindungsspezifität: Extracellular Domain

Verwendungszweck: Anti-Cytokeratin 18 [HH156], Rabbit IgG, kappa

Spezifität: This antibody is specific for extracellular domain of the human cytokeratin 18 containing amino acids 'LEDGEDFNLGDALD'. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is widely expressed in human monolayer epithelial tissues, and generally appears in pairs with CK8. CK18 is a serum marker for a variety of tumor diagnosis, as well as a serum marker for liver injury. It is involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing BALB/c mice with human cytokeratin 18 extracellular domain polypeptide 'LEDGEDFNLGDALD'. Later on the humanized version of this antibody was generated by grafting the CDRs of the original mouse antibody E156 onto human framework regions.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody can bind human cytokeratin 18 in an ELISA. The original IgG1 version of this antibody is reported to bind human cytokeratin 18 with a binding affinity of 32.8 pM.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Andere Bezeichnung: Cytokeratin 18

Hintergrund: CK18, CK-18, CK 18, KRT18, CYK18, Keratin type I cytoskeletal 18, Cytokeratin-18, Cell proliferation-inducing gene 46 protein

UniProt: P05783

Pathways: Apoptose, Caspase Kaskade in der Apoptose