Rekombinanter CD3 Antikörper
Kurzübersicht für Rekombinanter CD3 Antikörper (ABIN7543307)
Target
Alle CD3 Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Anti-CD3 [CD3B219], Human IgG4, lambda
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Spezifität
- The antibody is specific for CD3 epsilon.
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Kreuzreaktivität
- Affe
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Produktmerkmale
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Original Species of Ab: Human
Original Format of Ab: IgG4
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Aufreinigung
- Protein A affinity purified
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Isotyp
- IgG4 lambda
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anti-CD3 (CD3) antibody
CD3 Reaktivität: Human, Maus, Ratte IHC, IF, WB Wirt: Kaninchen Polyclonal unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human, Non-Human Primate FACS, IP, IHC (fro), ICC, MS Wirt: Maus Monoclonal UCHT1 unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human, Non-Human Primate FACS, IP, IHC (fro), Func, MS Wirt: Maus Monoclonal UCHT1 unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human FACS, IP, Func, MS Wirt: Maus Monoclonal MEM-57 unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human FACS, IP, MS Wirt: Maus Monoclonal MEM-57 unconjugated
anti-CD3 (CD3) antibody (Biotin)CD3 Reaktivität: Human, Non-Human Primate FACS, IP, IHC (fro) Wirt: Maus Monoclonal UCHT1 Biotin
anti-CD3 (CD3) antibody (Biotin)CD3 Reaktivität: Human FACS, IP Wirt: Maus Monoclonal MEM-57 Biotin
anti-CD3 (CD3) antibody (PerCP)CD3 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal UCHT1 PerCP
anti-CD3 (CD3) antibody (APC)CD3 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal UCHT1 APC
anti-CD3 (CD3) antibody (PE)CD3 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal UCHT1 PE
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Applikationshinweise
- The antibody was used to construct different CD33 xCD3 bispecific antibodies (IgG4). In vitro T cell mediated cytotoxicity assays were performed using the bispecific antibody and the cytotoxicity was measured by flow cytometry. Ex vivo cytotoxicity assay showed the paired antibody promoted a dose-dependent reduction of total cytotoxicity that correlated with T cell activation after 48 hours (US20210040209A1). The antibody is considered a high affinity binder (Kd= 8 mM) (US20210214440A1). The CD33xCD3 bispecific antibodies specifically induce cell cytotoxicity of MOLM-13 cells and CD33+ monocytes at 48 hr (US20200048349A1).
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD3
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Andere Bezeichnung
- CD3
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Hintergrund
- T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, SP34-2
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UniProt
- P07766
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Pathways
- T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
Target
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