Rekombinanter CD3 Antikörper

Produktnummer ABIN7543307

Dieser Human Monoklonal Antikörper detektiert spezifisch CD3 in FACS und in vitro. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter CD3 Antikörper (ABIN7543307)

Target: CD3

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser CD3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), In vitro Assay (in vitro)

Klon: CD3B219

Produktdetails anti-CD3 Antikörper

Verwendungszweck: Anti-CD3 [CD3B219], Human IgG4, lambda

Spezifität: The antibody is specific for CD3 epsilon.

Kreuzreaktivität: Affe

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG4

Aufreinigung: Protein A affinity purified

Isotyp: IgG4 lambda

Anwendungsinformationen

Applikationshinweise: The antibody was used to construct different CD33 xCD3 bispecific antibodies (IgG4). In vitro T cell mediated cytotoxicity assays were performed using the bispecific antibody and the cytotoxicity was measured by flow cytometry. Ex vivo cytotoxicity assay showed the paired antibody promoted a dose-dependent reduction of total cytotoxicity that correlated with T cell activation after 48 hours (US20210040209A1). The antibody is considered a high affinity binder (Kd= 8 mM) (US20210214440A1). The CD33xCD3 bispecific antibodies specifically induce cell cytotoxicity of MOLM-13 cells and CD33+ monocytes at 48 hr (US20200048349A1).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD3

Target: CD3

Andere Bezeichnung: CD3

Hintergrund: T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, SP34-2

UniProt: P07766

Pathways: T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway