Rekombinanter TIGIT Antikörper

Produktnummer ABIN7543291

Dieses Anti-TIGIT-Antikörper ist ein Human Monoklonal-Antikörper zur Detektion von TIGIT in ELISA, FACS und BR. Geeignet für Human.

Kurzübersicht für Rekombinanter TIGIT Antikörper (ABIN7543291)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser TIGIT Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Blocking Reagent (BR)

Klon: AET2010

Produktdetails anti-TIGIT Antikörper

Verwendungszweck: Anti-TIGIT [AET2010], Human IgG1, lambda

Spezifität: This antibody binds the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was isolated from a fully synthetic human single chain antibody phage display library by multiple rounds of bio panning against human TIGIT.

Isotyp: IgG1 lambda

Anwendungsinformationen

Applikationshinweise: The binding characterization of this antibody for TIGIT was done using ELISA. The IgG1 version of this antibody binds human TIGIT with a binding affinity of Kd= 3.74 nM. This antibody is also capable of blocking the binding of TIGIT to its ligand CD155. The binding of this antibody to membrane bound TIGIT was determined using flow cytometry. The anti-tumor activity of this antibody was tested against NK-92MI cells in vitro. It was also reported that AET 2010 exhibits enhanced anti-tumor activity in the CDX mouse model of NK-92MI cells (CN112679610).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Andere Bezeichnung: TIGIT

Hintergrund: VSTM3, VSIG9, WUCAM, T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3

UniProt: Q495A1

Pathways: Cancer Immune Checkpoints