Rekombinanter TNFSF4 Antikörper

Produktnummer ABIN7543010

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch TNFSF4 in FACS, IHC (fro) und BP. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für Rekombinanter TNFSF4 Antikörper (ABIN7543010)

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser TNFSF4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Peptide (BP)

Klon: OX-89

Produktdetails anti-TNFSF4 Antikörper

Verwendungszweck: Anti-OX40L [OX-89], Rabbit IgG, kappa

Spezifität: This antibody is specific for murine CD252 (the ligand for OX40), expression of which is restricted to activated B cells, dendritic cells, microglia and endothelial cells.

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was prepared by immunizing PVG rats with a recombinant chimeric protein consisting of domains 3 and 4 of rat CD4 and the extracellular region of mouse CD134L.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds mouse CD134L, and has been shown to bind activated B cells and DCs, as well as CD134L-transfected fibroblast cells, though not activated T cells, in labelling and immunohistochemical analysis (Malmstro m, 2001). In addition, this antibody is able to partially block the interaction between CD134 and CD134L. This blocking effect could be responsible for the ability of this antibody to prevent T cell accumulation in the intestine of T cell-restored SCID mice and inhibits the development of Th1-mediated colitis.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu TNFSF4

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Andere Bezeichnung: OX40L

Hintergrund: CD252, Tumor necrosis factor ligand superfamily member 4, OX40 ligand, CD134 ligand, OX40R

UniProt: P43488

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints