ADAM17 Antikörper (AA 497-671)

Produktnummer ABIN7539772

Der Maus Monoklonal Anti-ADAM17-Antikörper wurde für WB, ELISA, FACS und ICC validiert. Er ist geeignet, ADAM17 in Proben von Human und Maus zu detektieren.

Kurzübersicht für ADAM17 Antikörper (AA 497-671) (ABIN7539772)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ADAM17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 7A6B2

Produktdetails anti-ADAM17 Antikörper

Bindungsspezifität: AA 497-671

Verwendungszweck: CD156B Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD156B (AA: 497-671) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Andere Bezeichnung: CD156B

Hintergrund: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2.

Molekulargewicht: 93 kDa

Gen-ID: 6868

UniProt: P78536

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus