EPH Receptor A7 Antikörper (AA 181-280) (Biotin)

Produktnummer ABIN722007

This anti-EPH Receptor A7 antibody (ABIN722007) is a Rabbit Polyclonal antibody detecting EPH Receptor A7 in WB, ELISA, IHC (p), IHC (fro). Suitable for Human, Rat, Mouse.

Kurzübersicht für EPH Receptor A7 Antikörper (AA 181-280) (Biotin) (ABIN722007)

Target: EPH Receptor A7 (EPHA7)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A7 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-EPH Receptor A7 Antikörper (Biotin)

Bindungsspezifität: AA 181-280

Spezifität: There is a chance that this protein will cross-react with EphA4 based on a 73 % non-sequential sequence similarity.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EphA7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Andere Bezeichnung: EphA7

Hintergrund:

Synonyms: EHK3, EK11, EHK-3, HEK11, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11, EPHA7

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Gen-ID: 2045

UniProt: Q15375

Pathways: RTK Signalweg