Insulin Receptor Antikörper
Kurzübersicht für Insulin Receptor Antikörper (ABIN7538096)
Target
Alle Insulin Receptor (INSR) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Rabbit polyclonal antibodies to Insulin Receptor
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Spezifität
- Insulin receptor
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Kreuzreaktivität (Details)
- May cross-react with other species
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Aufreinigung
- Immunogen affinity column
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Immunogen
- Peptide conjugated to KLH (GGKKNGRILTLPRSNPS)
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Isotyp
- IgG, IgM
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Applikationshinweise
- Western blot: 0.1-1.0 μg/mL
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- Glycine pH 7.2
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Lagerung
- 4 °C,-80 °C
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Informationen zur Lagerung
- Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C
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- Insulin Receptor (INSR)
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Andere Bezeichnung
- insulin receptor
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Hintergrund
- INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
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Molekulargewicht
- 42226 Da
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Gen-ID
- 3643
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NCBI Accession
- NP_000199
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UniProt
- P06213
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Pathways
- NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
Target
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