PPM1D Antikörper

Produktnummer ABIN7506006

Dieser Maus Monoklonal Antikörper erkennt spezifisch PPM1D in WB, ELISA, IHC (p), ICC und ICFC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für PPM1D Antikörper (ABIN7506006)

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPM1D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Intracellular Flow Cytometry (ICFC)

Klon: 7E11-C5

Produktdetails anti-PPM1D Antikörper

Verwendungszweck: Anti-PPM1D Purified

Spezifität: The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.

Aufreinigung: Purified by protein-A affinity chromatography.

Immunogen: Purified human PPM1D

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blotting: Recommended dilution: 1-2 μg/mL.
Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Andere Bezeichnung: PPM1D

Hintergrund: Protein phosphatase, Mg2+/Mn2+ dependent 1D,PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.,WIP1, Protein phosphatase 1D, JDVS, WIP1, IDDGIP

Gen-ID: 8493

UniProt: O15297

Pathways: p53 Signalweg, Zellzyklus