The clone 962C1, a mouse monoclonal antibody, reacts with the human CD41 Molecule, the integrin alpha-IIb also known as platelet GPIIb. CD41 is composed of two subunits GPIIbα (120 kDa) and GPIIbβ (23 kDa) that interact with CD61 to form a functional protein receptor in the presence of calcium. This protein receptor involves in the blood coagulation system, by mediating platelet adhesion and aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins like von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocytes and platelets. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder
Aufreinigung
Purified
Reinheit
>95 %
Immunogen
Recombinant full-length human Integrin alpha IIb protein
We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.