Rekombinanter CD3 Antikörper

Produktnummer ABIN7488633

Der Maus Monoklonal anti-CD3 Antikörper wird verwendet zum Nachweis von CD3 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für Rekombinanter CD3 Antikörper (ABIN7488633)

Target: CD3

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: SP34-2

Produktdetails anti-CD3 Antikörper

Verwendungszweck: Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2)

Immunogen: Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293). The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with CD3.

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Lagerung: -20 °C

Details zu CD3

Target: CD3

Andere Bezeichnung: CD3

Hintergrund: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Pathways: T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway