Retinoblastoma Binding Protein 4 Antikörper (AA 1-425)

Produktnummer ABIN7468875

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Retinoblastoma Binding Protein 4 in WB, IHC, IF, IP und ICC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Retinoblastoma Binding Protein 4 Antikörper (AA 1-425) (ABIN7468875)

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma Binding Protein 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: 13D10

Produktdetails anti-Retinoblastoma Binding Protein 4 Antikörper

Bindungsspezifität: AA 1-425

Kreuzreaktivität: Human

Aufreinigung: Protein G purified

Immunogen: The complete coding region (amino acids 1-425) of RbAp48 expressed in E. coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLa nuclear extract , SH-SY-5Y , SH-SY-5Y nuclear extract Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Retinoblastoma Binding Protein 4

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Andere Bezeichnung: RB binding protein 4, chromatin remodeling factor

Hintergrund:

Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Molekulargewicht: 48 kDa

Gen-ID: 5928

UniProt: Q09028

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus