PD-1 Antikörper

Produktnummer ABIN7457957

Dieses Anti-PD-1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PD-1 in FACS, Neut und BR. Geeignet für Human.

Kurzübersicht für PD-1 Antikörper (ABIN7457957)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Neutralization (Neut), Blocking Reagent (BR)

Klon: J116

Produktdetails anti-PD-1 Antikörper

Aufreinigung: Purified

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Matching Isotype Control: AF/LE Purified Mouse IgG1, κ Isotype Control (ABIN7469767)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2~8°C. Do not freeze.

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: CD279/PD-1

Hintergrund: PD-1, Programmed Death-1,Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Gen-ID: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints