CSF1R Antikörper

Produktnummer ABIN7457933

Dieses Anti-CSF1R-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CSF1R in FACS, BR, Dep und Neut. Geeignet für Maus.

Kurzübersicht für CSF1R Antikörper (ABIN7457933)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CSF1R Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Blocking Reagent (BR), Depletion (Dep), Neutralization (Neut)

Klon: AFS98

Produktdetails anti-CSF1R Antikörper

Aufreinigung: Purified

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Matching Isotype Control: AF/LE Purified Rat IgG2a, κ Isotype Control (ABIN7469836)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2~8°C. Do not freeze.

Details zu CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Andere Bezeichnung: CD115

Hintergrund: Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms,CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Gen-ID: 12978

UniProt: P09581

Pathways: RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization