PD-1 Antikörper (PE-Cy7)

Produktnummer ABIN7457575

Der Ratte Monoklonal Anti-PD-1-Antikörper wurde für FACS validiert. Er ist geeignet, PD-1 in Proben von Maus zu detektieren.

Kurzübersicht für PD-1 Antikörper (PE-Cy7) (ABIN7457575)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist konjugiert mit PE-Cy7

Applikation: Flow Cytometry (FACS)

Klon: 29F-1A12

Produktdetails anti-PD-1 Antikörper (PE-Cy7)

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume].

Kommentare:

Matching Isotype Control: PE/Cyanine7 Rat IgG2a, κ Isotype Control (ABIN7469844)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: CD279/PD-1

Hintergrund: PD-1, Programmed Death-1,CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Gen-ID: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints