PARN Antikörper (AA 589-639)

Produktnummer ABIN7454930

Dieses Anti-PARN-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PARN in WB, IP und IHC (fp). Geeignet für Human und Maus.

Kurzübersicht für PARN Antikörper (AA 589-639) (ABIN7454930)

Target: PARN (Poly A Specific Ribonuclease (PARN))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-PARN Antikörper

Bindungsspezifität: AA 589-639

Verwendungszweck: Rabbit anti-PARN Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 589 and 639

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PARN

Target: PARN (Poly A Specific Ribonuclease (PARN))

Andere Bezeichnung: PARN

Hintergrund: Background: Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. PARN prefers poly(A) as the substrate, hence, it efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. PARN is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons [taken from NCBI Entrez Gene (Gene ID: 5073)].

Gen-ID: 5073

NCBI Accession: NP_002573

UniProt: O95453