TARDBP Antikörper (AA 250-300)

Produktnummer ABIN7454906

Dieses Anti-TARDBP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TARDBP in WB, IP und IHC (fp). Geeignet für Human und Maus.

Kurzübersicht für TARDBP Antikörper (AA 250-300) (ABIN7454906)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-TARDBP Antikörper

Bindungsspezifität: AA 250-300

Verwendungszweck: Rabbit anti-TDP43 Antibody, Affinity Purified

Homologie: Chicken,Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 250 and 300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: TDP43

Hintergrund: Background: Tar DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing. It is involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP43 may also be involved in microRNA biogenesis, apoptosis and cell division. TDP43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Also, TDP43 stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR [taken from the Universal Protein Resource (UniProt) Q13148].

Gen-ID: 23435

NCBI Accession: NP_031401

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion